Effect of Bronchofibroscope Lavage Combined with Acetylcysteine Effervescent Tablets on Pulmonary Ventilation Function of Patients with Pneumoconiosis

WU Yong-sheng; FANG Qing; SONG Li-ming

doi:10.3969/j.issn.1002-3429.2017.11.019

Abstract：Objective To investigate effect of bronchofibroscope alveolar lavage combined with Acetylcysteine Effer-vescent Tablets on pulmonary ventilation function of patients with pneumoconiosis. Methods A total of 72 patients with pneu-moconiosis were divided into control group (n=36) and observation group (n=36) according to the hospitalization time. Ob-servation group was treated with bronchofibroscope alveolar lavage combined with Acetylcysteine Effervescent Tablets on the basis of conventional therapy, while control group was treated with Acetylcysteine Effervescent Tablets on the basis of conven-tional therapy. Blood gas analysis and pulmonary ventilation function indexes were observed and compared before and after treatment for 30 d between the two groups. Results There were no significant differences in blood gas analysis and pulmonary ventilation function indexes between two groups (P>0. 05). After treatment for 30 d, levels of partial pressure of carbondiox-ide (PaCO2) and total lung capacity (TLC) were significantly lower, while levels of partial pressure of oxygen (PaO2), forced expiratory volume in 1 second ( FEV1 ) and vital capacity ( VC) were significantly higher than those before treatment in observation group (P<0. 05); in control group, PaCO2 and TLC levels were significantly lower than those before treatment (P<0. 05). After treatment for 30 d, in observation group, PaCO2 and TLC levels were significantly lower, while PaO2, FEV1 and VC levels were higher than those in control group ( P <0. 05 ) . Conclusion Bronchofibroscope alveolar lavage combined with Acetylcysteine Effervescent Tablets can effectively improve pulmonary ventilation function and quality of life of patients with pneumoconiosis.