Cause Analysis of 2 Misdiagnosed Patients with Primary Marchiafava-Bignami Disease
LI Bo
XU Xiu-hong
XU Yu
YAN Jia-lan
WEI Shi-xian
WANG Xue-li
Abstract：Objective To investigate clinical features, diagnosis and treatment methods, misdiagnosed causes and preventive measures of primary Marchiafava-Bignami disease ( MBD ) . Methods Clinical data of 2 patients with primary MBD was retrospectively analyzed, and related literatures were reviewed. Results The 2 patients were middle-aged male with a long term history of heavy alcohol consumption, and were admitted for blurred vision and diplopia for 1 month and dizziness and torpid reaction for 2 months accompanied by memory impairment and gait ataxia for more than 10 days respectively. The 2 patients were misdiagnosed as having cerebral infarction, but the conditions were not relieved after corresponding treatments. After admission in our hospital, chronic encephalopathia alcoholic and primary MBD was confirmed by examination such as magnetic resonance imaging ( MRI) , and then the 2 patients were relieved and discharged after treatments of high-dose of vita-min B group and appropriate amount of glucocorticoid in early stage of disease. Conclusion The etiological factor of primary marchiafava-bignami disease is chronic alcoholism, and its clinical manifestations are lack of specific, and therefore clinicians should pay attention to differential diagnosis with cerebral infarction. The special MRI changes contribute the diagnosis.
Keywords：Marchiafava-Bignami diseaseMisdiagnosisBrain infarction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 35-38 )