Value of Combined Detection of EB Virus Antibody and Its DNA in Diagnosis of Infectious Mononucleosis Syndrome in Infants and Young Children
LIU Jie
CHENG Lu-shan
JING Cheng-bao
Abstract：Objective To analyze value of combined detection of epstein-barr virus ( EBV) antibodies and EBV-DNA in diagnosis of infectious mononucleosis syndrome ( IMS) in infants and young children. Methods A total of 120 infants and young children with IMS admitted during January 2014 and May 2016 were recruited in this study. In the 1st, 2nd, 3rd and 4th weeks after admission, EBV-immunoglobulin M ( IgM) levels were detected using enzyme linked immunosorbent assay;EBV-DNA values was detected using fluorescent quantitation;combined detection of EBV-IgM and EBV-DNA were also performed. Positive rates of 3 methods were compared. Results Positive rates in the 1st, 2nd, 3rd and 4th weeks after admission by EBV-IgM and combined detections were significantly higher than those of EBV-DNA, and the positive rates of combined detection in the 1st and 2nd weeks after admission were significantly higher than those of EBV-IgM detection (P<0. 05 or P<0. 01). There were no statistically significant differences in the 3 rd and 4 th weeks after admission between combined detection and EBV-IgM detection ( P>0. 05 ) . Conclusion EBV-IgM detection is more sensitive for early diagnosis of infants and young children with IMS, and early combined detection of EBV-IgM and EBV-DNA can further increase diagnostic rate.
Keywords：Infectious mononucleosisEpstein-Barr virus antibodiesEpstein-Barr virus DNA
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 88-90 )