Effects of Chemotherapy Drugs on Oxidative Stress of Peripheral Bloods in Vocational Contact Nurses

PAN Dan-dan; WANG Lan; YANG Xue-yan; ZHAO Tian-xin; YAN Li-mei

doi:10.3969/j.issn.1002-3429.2017.09.034

Abstract：Objective To observe effects of chemotherapy drugs on relevant indexes of oxidative stress of peripheral bloods in vocational contact nurses.Methods Nurses who worked on departments related to tumor chemotherapy at the end of 2015 were selected as observation group (n=55), and other nurses who worked on clinical departments without contacting tumor chemotherapy drugs at the same period were selected as control group (n=55).Changes of relevant oxidative stress indexes [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and catalase (CAT)] of peripheral bloods were observed in two groups, and correlations between contact time and total professional risk indexes with relevant indexes of oxidative stress of peripheral bloods were analyzed in observation group.Results Compared with those in control group, in observation group, MDA level was significantly increased, while SOD, GSH-Px and CAT levels of peripheral bloods were significantly decreased (P<0.05).Compared with those in short-time contact group (<2.76 years), in long-time contact group, MDA level was significantly increased, while GSH-Px, SOD and CAT levels of peripheral blood were significantly decreased (P<0.05).Compared with those in low-risk group, in high-risk group (occupational risk indexes≥ 285.70), MDA level was significantly increased, while GSH-Px, SOD and CAT levels of peripheral blood were significantly decreased (P<0.05).Conclusion Chemotherapy drugs may obviously affect relevant indexes of oxidative stress of peripheral bloods in vocational contact nurses, and the effect positively correlates with contact time and total professional risk indexes.