Clinical Effects of Ambrette Capsules Combined with Valsartan in Treatment of Early Renal Damage in Patients with Hypertension

WANG Zhen; HE Yi-xian; ZHANG Jing-wen

doi:10.3969/j.issn.1002-3429.2017.09.028

Abstract：Objective To investigate clinical effects of Ambrette Capsules combined with Valsartan in treatment of early renal damage in patients with hypertension.Methods A total of hypertension 96 patients with early renal damage admitted during January 2013 and December 2016 were divided into control group and observation group (n=48 for each group) according to their admission order.All patients were treated with conventional therapy and 80 mg/d Valsartan orally.Observation group was added with Ambrette Capsule (5 capsules/time, 3/d) on this basis treatment.Levels of blood pressure, serum creatinine (Scr), urea (BUN), serum cystatin (Cys-C), 24 h urinary protein and superoxide dismutase (SOD) changes were detected after 1 month of treatment, and clinical effects were observed, and incidence rates of adverse reactions were also recorded in two groups.Results Compared with those before treatment, blood pressure, Scr, BUN, Cys-C and 24 h urinary protein levels were significantly decreased, while SOD levels were significantly increased after treatment in the same group in two groups (P<0.05).Compared with those in control group, blood pressure, Scr, BUN, Cys-C and 24 h urinary protein levels were significantly decreased, while SOD level was significantly increased after treatment in observation group (P<0.05).The total effective rate in observation group (95.83％) was significantly higher than 79.17％ in control group (P<0.05).There was no significant difference in incidence rate of adverse reactions between the two groups (P>0.05).Conclusion Ambrette Capsules combined with Valsartan has a certain protective effect on renal function in hypertension patients with early renal damage, and therefore it can be used as the first choice for clinical treatment.