Expressions and Clinical Significances of SSA Antibody, SSB Antibody and SS56 in Labial Gland Tissues of Patients with Sjogren's Syndrome

DU Wang-lei; YANG Xi-Chao; XIE Rong-hua; ZHU Ping

doi:10.3969/j.issn.1002-3429.2017.08.023

Abstract：Objective To investigate expressions and clinical significances of SSA antibody, SSB antibody and SS56 in labial gland tissues of patients with sjogren''s syndrome (SS).Methods A total of 50 SS patients admitted during February 2012 and February 2015 were selected as SS group, while other 100 patients with non-ss autoimmune disease at the same period were selected as non-SS group, and 50 healthy people taking medical examination for health at the same period were selected as health group.Positive rates of SSA antibody, SSB antibody and SS56 between SS group and non-SS groups, grayscale values of SSA antibody, SSB antibody and SS56 among the three groups, and clinical features and laboratory examination results between negative and positive SS patients were compared.Results Positive rates of SSA antibody, SSB antibody and SS56 in SS group were significantly higher than those in non-SS group (P<0.05).The differences in grayscale values of SSA antibody, SSB antibody and SS56 were statistically significant among the three groups (P<0.05).Grayscale values of SSA antibody, SSB antibody and SS56 in health group were significantly higher than those in non-SS and SS groups, and the grayscale values of SSA antibody, SSB antibody and SS56 in SS group were significant higher than those in non-SS group (P<0.05).In negative SS56 SS patients, red blood cell (RBC) and hemoglobin levels were significantly higher, while erythrocyte sedimentation rate (ESR) was significantly lower than those in positive SS56 SS patients (P<0.05).Conclusion SSA antibody, SSB antibody and SS56 show positive expressions in labial glands tissues of patients with SS, and therefore they can be used as diagnostic indexes for SS.