Expression and Significance of Serum Gastrin-17 in Patients with Colonic Polyps

XU Qian; FENG Ru; LYU Yong-jian; YUE Su-yang; FEI Su-juan

doi:10.3969/j.issn.1002-3429.2017.07.026

Abstract：Objective To investigate correlation between serum gastrin-17 (G-17) and colonic polyps pathogenesy, and to evaluate its diagnostic value in screening colonic polyp.Methods A total of 194 cases of colonic polyps during December 2015 and October 2016 were selected as colonic polyps group, and other 100 cases without colonic abnormalities at the same period were chosen as control group.Serum G-17 levels and G-17 positive rates were detected by enzyme-linked immunosorbent assay (ELISA), and receiver operating curve (ROC) was drawn further to find the best cut-off value in diagnosis of colonic polyps.Relationships between serum G-17 level and pathological types, lesion locations and number of colonic polyps were observed by subgroup analysis of colonic polyps.Results In colonic polyps group, serum G-17 level was significantly higher (t=7.513, P=0.000), and the positive rate of G-17 was significantly higher than those in control group (χ2=91.424, P=0.000).ROC showed that the best cut-off value of G-17 in diagnosis of colonic polyps was 15.16 pmol/L, and diagnostic sensitivity and specificity were 61.7% and 81.2% respectively.The subgroup analysis of colonic polyps group showed that the G-17 level was significantly higher in the subgroup of adenomatous polyposis with higher malignant degree than those in inflammatory, proliferative and mixed polyps subgroups, and the differences were statistically significant (vs inflammation subgroup: t=3.265, P=0.002;vs hyperplasia subgroup: t=2.210, P=0.039;vs mixed subgroup: t=2.122, P=0.034);but G-17 levels showed no relationships with the location and number of polyps.Conclusion Serum G-17 may be associated with pathogenesy and pathological types of colonic polyps, and it is expected to be a method for clinical prediction and screening of colonic polyps.