Clinical Characteristics and Related Factors of Infants with Primary Severe Congenital Syphilis

NI Qi-fei; XU Wei

doi:10.3969/j.issn.1002-3429.2017.07.023

Abstract：Objective To analyze clinical characteristics, influencing factors of onset and related factors of death in infants with primary severe congenital syphilis.Methods A total of 82 infants with primary congenital syphilis admitted during January 2011 and January 2017 were divided into severe group (n=39) and common group (n=43) according to disease severity.Clinical data of infants was retrospectively analyzed, and clinical features of infants with primary congenital syphilis were summarized, and onset factors and related factors of fatality in severe group were analyzed.Results Results of serum treponema pallidum particle assay (TPPA) and rapid plasma reagent (RPR) of the 82 infants were positive, and the titer values were four times higher than those of mother's.In severe group, clinical characteristics were mainly skin mucomembranous injury, gastrointestinal function injury and pulmonary injury, and all infants had multiorgans dysfunction, and fatality rate was 22.22% (8/36).Related factors of influencing fatality were younger infants, premature infant, infants in countryside and longer duration of onset for infants with primary severe congenital syphilis (P<0.05).Single factor analysis showed that premature infant, whether or not having mechanical ventilation and numbers of multiorgans dysfunction were the risk factors of fatality.Conclusion Skin mucomembranous injury, gastrointestinal function injury and pulmonary injury are main clinical characteristics of infants with primary severe congenital syphilis, and the fatality rate is high, and therefore clinicians should pay more attention on the disease in order to early diagnosis and treatment and improve prognosis.