Correlation Analysis of Gastroesophageal Reflux Disease and Hypertensive Disease
LI Zhi-tong
JI Feng
HAN Xin-wei
WANG Zhong-gao
WANG Li
XU Miao
YUE Yong-qiang
Abstract：Objective To observe correlation between gastroesophageal reflux disease (GERD) and primary hypertensive disease.Methods A total of 22 primary hypertensive disease patients with GERD admitted during June 2014 and December 2015 were given Omeprazole treatment for 1 month and invariable anti-hypertension therapy.The 24 h ambulary blood pressure monitoring and 24 h esophageal pH associated impedance monitoring were performed before and after treatment simultaneously, and correlation between pathological reflux and onset of hypertensive disease.blood pressure (BP) changes and anti-hypertension effect of anti-acid therapy were observed.Results During the monitoring, 312 times of pathological reflux (PR) and 453 times of elevated BP were recorded.Nocturnal PR was more easily found (t=-2.888, P=0.009), while there was no significant difference in times of hypertension onset in the day and night (t=0.990, P=0.333).PR was correlated with hypertension onset (r=0.242, P=0.015).Anti-acid therapy brought about different degrees reduction in all esophageal monitoring parameters and BP parameters (P<0.05 or P<0.01).The total effective rate of anti-acid therapy for anti-hypertension was 54.5%.Conclusion Partial hypertension is closely related to GERD.Effective diagnosis and active treatment can significantly ameliorate reflux symptoms and reduce incidence rate of related hypertensive diseases.
Keywords：HypertensionGastroesophageal refluxBlood pressure monitoringEsophageal pH monitoring
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 53-56 )