Correlation between Levels of Receptor for Advanced Glycation End Products and Aquaporin 5 with Severity of Neonatal Respiratory Distress Syndrome
LIU Chun-zhi
MEI Hua
Abstract：Objective To investigate correlation between receptor for advanced glycation end products (RAGE) and aquaporin 5 (AQP5) with severity of neonatal respiratory distress syndrome (RDSN).Methods A total of 78 patients with RDSN admitted during January 2014 and January 2016 were selected as observation group;, and 78 healthy neonates at the same period were collected as control group.Changes of RAGE and AQP5 levels between the two groups were compared, and correlations among severity of the disease, gestational age and prognosis with RAGE and AQP5 levels were analyzed.Results Compared with those in control group, RAGE and AQP5 levels were significantly increased (P=0.000).RAGE and AQP5 levels were closely correlated with gestational age and severity of the disease (P=0.000).The area under curve of RAGE in diagnosis of unfavourable prognosis of RDSN was 0.775 (95% IC: 0.616-0.934, P=0.011);and the curve area of AQP5 in the diagnosis of in-hospital mortality in neonatal respiratory distress syndrome was 0.775 [95% confidence interval (CI): 0.616-0.934, P=0.011], while area under curve of AQP5 in diagnosis of unfavourable prognosis of RDSN was 0.739 (95% CI:0.580-0.899, P=0.027).Conclusion RAGE and AQP5 levels are significantly increased in RDSN neonates, and the levels are closely related to severity of the disease, gestational age and prognosis.
Keywords：Respiratory distress syndromenewbornReceptor for advanced glycation end productsAquaporin 5
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 96-99 )