Effect of Negative Pressure Wound Therapy on EDA+ FN Level in Different Ischemia Granulation Tissues of Diabetic Foot Wounds
YANG Shao-ling
ZHU Lyu-yu
HU Li-ye
LIU Yang
WU Shan
Abstract：Objective To investigate effect of negative pressure wound therapy (NPWT) on EDA+ FN level in different ischemia granulation tissue of diabetic foot wounds.Methods A total of 30 diabetic feet fitting the inclusion criteria during January 2014 and January 2016 were divided into 0.5≤ABI<0.7 group (n=15) and 0.7≤ABI≤0.9 group (n=15) according to ABI (ankle brachial index) value.All patients received NPWT.Granulation tissues of wounds were collected before treatment and at the 14th d of treatment to observe the changes of EDA+ FN.Results Compared with those before treatment in same group, values of area density of EDA+ FN, relative protein expression of EDA+ FN and relative mRNA expression of EDA+ FN were significantly increased after treatment in both groups (P<0.01).After treatment, values of area density of EDA+ FN, relative protein expression of EDA+ FN and relative mRNA expression of EDA+ FN in 0.7≤ABI≤0.9 group were significantly higher than those in 0.5≤ABI<0.7 group (P<0.01).Conclusion NPWT has different effects on EDA+ FN levels in different ischemia granulation tissue of diabetic foot wounds.EDA+ FN levels in different ischemia granulation tissue of diabetic foot wounds may decrease with aggravated ischemia degree.
Keywords：Diabetic footNegative pressure wound therapyGranulation tissue
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 92-96 )