Sequential Low Molecular Heparin after Alteplase Thrombolytic Therapy in Treatment of Elderly Patients with Acute Massive Pulmonary Embolism
CHEN Dong-li
XIE Zhao-feng
WANG Xian-qi
Abstract：Objective To investigate clinical effect and safety of sequential low molecular heparin anticoagulation after Alteplase thrombolytic therapy in treatment of elderly patients with acute massive pulmonary embolism (AMPE).Methods A total of 100 elderly patients with AMPE admitted during January 2011 and November 2015 were divided into treatment group and control group (n=50 for each group) according to random digits table method.All patients received supporting therapy.Treatment group was treated with sequential low molecular heparin anticoagulation therapy after Alteplase thrombolytic therapy, while control group was treated with sequential low molecular heparin anticoagulant therapy after Urokinase thrombolytic therapy.Changes of arterial blood gas and right ventricular function were observed, and curative effect and incidence rate of adverse reaction were recorded in two groups.Results Compared with those before treatment, arterial blood gas and right ventricular function were improved after treatment in two groups, and the differences were statistically significant (P<0.05).Arterial blood gas and right ventricular function were significantly improved after treatment in treatment group compared with those in control group (P<0.05).In treatment group, the total effective rate (94.00%) was significantly higher than that 80.00% in control group, and the mild and severe bleeding and death rates were significantly lower (P<0.05).Conclusion Sequential low molecular heparin anticoagulation after Alteplase thrombolytic therapy in treatment of elderly patients with acute massive pulmonary embolism is effective and safe.
Keywords：Massive pulmonary embolismacuteAgedTissue-type plasminogen activatorHeparinlow-molecular-weight
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 70-74 )