A Report of 4 Cases and Literatures Review of Hemophagocytic Syndrome
ZHANG Qian
BAI Hai
WANG Cun-bang
ZHAO Li-ping
LU Xiao-ya
PAN Yao-zhu
XUE Feng
Abstract：Objective To analyze clinical features, diagnosis and treatment of hemophagocytic syndrome (HPS) in order to avoid misdiagnosis and mistreatment.Methods Clinical data of 4 patients with HPS was retrospectively analyzed, and related literature was also reviewed.Results The main manifestation of the 4 patients was fever.Among them, one was confirmed the diagnosis immediately after hospitalization;other three patients were misdiagnosed as having upper respiratory tract infection combined with leucopenia, and symptoms such as fever, hyperlipidemia, coagulation disorders, thrombocytopenia and abnormally elevated serum ferroprotein were all found in four patients.Bone marrow aspiration of cytological examination showed that three patients had hemophagocytic cells, and HPS was confirmed;one was confirmed as having HPS by clinical manifestations and laboratory examinations.Symptomatic treatments such as glucocorticoid, anti-infection and immunosuppressive therapy were given, but the symptoms were not relieved, and then all patients died of multiorgan failure.Conclusion Clinical manifestations of HSP is diversified with rapid development.Clinicians should consider the possibility of HSP for patients having fever of undetermined origin for more than 1 week and poor effect of anti-infection therapy, and give related examinations as early as possible to avoid misdiagnosis and mistreatment.
Keywords：Hemophagocytic syndromeFeverMisdiagnosisUpper respiratory tract infectionsLeukopenia
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 38-41 )