Castleman Disease With Renal Failure as an Initial Symptom: a Case Report and Literature Review
LIAO Ying
WAN Qi-jun
HUANG Hao-gui
Abstract：Objective To discuss clinical and pathological characteristics of Castleman disease with renal failure as an initial symptom.Methods Clinical data of one Castleman disease patient with renal failure as an initial symptom was retrospectively analyzed.Results The patient went to hospital because of edema and abnormal urine colour for 10 months and abnormal renal function for 4 months.The patient was diagnosed as having chronic kidney insufficiency (uremia period), and the symptom did not relieve after peritoneal dialysis and other related treatments.Multicentric Castleman disease and chronic kidney disease (stage Ⅳ) was confirmed by results of bone marrow biopsy cytological examination, lymph node biopsy pathologic examination, immunohistochemical staining and pathologic examination for kidney tissue after admission.Chemotherapy and symptomatic treatment were given, and the patient was discharged after condition had improved.With follow-up for more than 8 years, the patient had no recurrence.Conclusion Clinicians should actively find causes of patients with acute kidney injury, and consider the possibility of Castleman disease when patients have multiple lymph nodes enlargement.Lymph node biopsy should be performed early to avoid misdiagnosis and mistreatment.
Keywords：Castleman diseaseGiant lymph node hyperplasiaMisdiagnosisUremia
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 36-38 )