Effects of Neuroendoscopy Assisted Transsphenoidal Microsurgery on Growth Hormone Level and Prognosis of Patients with Growth Hormone-secreting Pituitary Adenoma
HE Run-zhi
WANG Zhen-hai
KONG Shi-qi
WANG Hao
Abstract：Objective To analyze effects of neuroendoscopy assisted transsphenoidal microsurgery on growth hormone (GH) level and prognosis of patients with growth hormone-secreting pituitary adenoma.Methods A total of 33 patients with growth hormone-secreting pituitary adenoma treated by neuroendoscopy assisted transsphenoidal microsurgery during February 2008 and July 2015 were collected as study group, and 33 patients with growth hormone-secreting pituitary adenoma treated by transsphenoidal microsurgery at the same period were selected as control group.The operative condition, tumor resection rate, GH levels before and after operation, incidence rate of complications and disease recurrence rate were compared between the two groups.Results In study group, operative time was significantly longer;postoperative time of lying in bed and hospitalization time were significantly shorter;total resection rate was significantly higher, and the total incidence rate complications was significantly lower than those in control group (P<0.05).The difference of GH levels before operation between the two groups was not statistically significant (P>0.05);postoperative GH levels were significantly improved compared with those before operation in two groups, and the changes in study group were more superior to that in control group (P<0.05).There was no significant difference in recurrence rates between the two groups by follow-up 1 year later (P>0.05).Conclusion Neuroendoscopy assisted transsphenoidal microsurgery is effective in treatment of patients with growth hormone-secreting pituitary adenoma, and it can shorten postoperative time of lying in bed and hospitalization time, improve GH level, increase tumor total resection rate and decrease total incidence rate of complications.
Keywords：Growth hormone-secreting pituitary adenomaNeuroendoscopyTranssphenoidal microsurgeryGrowth hormonePrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 101-105 )