Expression Levels of Helper Lymphocyte T in Peripheral Blood of Patients with Chronic Hepatitis B, Liver Cirrhosis after Hepatitis B and Hepatocellular Carcinoma
HOU Chun-yang
MA Yu-mei
LIU Li
LI Zong-fen
Abstract：Objective To investigate expression levels of helper T lymphocyte (Th) in peripheral blood of patients with chronic hepatitis B (CHB), liver cirrhosis (LC) after hepatitis B infection and hepatocellular carcinoma (HCC).Methods A total of 34 hepatitis B virus (HBV) patients (CHB group) reported in legal infectious diseases network of Jianping County from January to March in 2014, 31 LC patients after hepatitis B infection (LC group) registered from January to December 2014, 29 HCC patients after hepatitis B infection (HCC group) registered in disease prevention and control center of Jianping County from January to March in 2014 and 30 healthy people taking physical examination from January to March in 2014 (control group) were recruited in this study.Detections of T cells (CD3+, CD4+, CD8+, CD4+/ CD8+) were performed for all the groups.Results There were significant differences in Th index values in peripheral blood in the four groups (P<0.05).Values of CD3+, CD4+ and CD4+/CD8+ in peripheral blood were significantly lower, while CD8+ values in peripheral blood were significantly higher in CHB, LC and HCC groups than those in control group;values of CD3+, CD4+ and CD4+/ CD8+ in peripheral blood were significantly lower, while CD8+ value was significantly higher in HCC group than those in CHB and LC groups;values of CD3+, CD4+ and CD4+/ CD8+ in peripheral blood was significantly lower, while CD8+ value was significantly higher in LC group than those in CHB group (P<0.05).Conclusion Abnormal expression of Th in peripheral blood can be found in patients with CHB, LC after hepatitis B infection and HCC after hepatitis B infection, and HCC patients after hepatitis B infection are especially severe.
Keywords：Hepatitis BchronicLiver cirrhosisLiver neoplasmsHelper T cellsPeripheral blood
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 98-101 )