Expression and Clinical Significance of p75NTR in Gastric Cancer

JIN Hai-feng; ZHAO Min; ZHAO Liang; WANG Li; WU Zheng; ZHAO Hui-dong; HOU Hui-chi; ZHU Yan-hua; SUN Rong; YAO Xin; WU Xiao-yun; GU Jian-fang

doi:10.3969/j.issn.1002-3429.2017.05.029

Abstract：Objective To analyze the expression and clinical significance of p75NTR in gastric cancer.Methods A total of 60 samples of gastric cancer undergoing surgical resection of gastric cancer during January 2015 and January 2016 were selected as the study subjects.The content of the study in accordance with the medical ethics will be approved and for patients to understand, signed an informed consent.Retrospective analysis of clinical data of all patients.The positive rate of p75NTR in patients with lymph node metastasis negative group, positive group and the depth of invasion of the muscle layer group, all patients were detected, the positive rate was statistically analyzed.The quality of life was compared between lymph node metastasis positive group and negative group after chemotherapy.Results The positive rate of p75NTR in lymph node metastasis negative group was significantly higher than that in lymph node metastasis positive group, and the difference was statistically significant (P<0.05).The positive rate of p75NTRin infiltration depth of muscular layer was significantly higher than that of the depth of infiltration whole layer group, and the difference was statistically significant (P<0.05).After treatment, the rating scales of viability, physical function, mental function and society function of lymph node metastasis negative patients were significantly higher than those of lymph node metastasis positive group, and the differences were statistically significant (P<0.05).Conclusion Expression of p75NTR in gastric carcinoma tissue can pretest cancerous tissue lymph node metastasis and invasion depth, and therefore clinical introduction of p75NTR index detection can basis as the effective prediction in prognosis of patients with gastric cancer.