Clinical Value of Neutrophil CD64 and C-reactive Protein in Peripheral Blood in Diagnosis of Burns Infection

REN Zhong-liang; XUE Jia-jie; GUO Lei; ZHENG Chao; WANG Yao-jun

doi:10.3969/j.issn.1002-3429.2017.05.026

Abstract：Objective To investigate clinical value of neutrophil CD64 and C-reactive protein (CRP) in peripheral blood in diagnosis of burn infection.Methods A total of 120 burns patients admitted during December 2015 and June 2016 were selected and divided into burns sepsis group, burns local infection group and burns without infection group (n=40 for each group).Levels of neutrophil CD64 and CRP in peripheral blood before treatment were detected in three groups;levels of neutrophil CD64 and CRP in peripheral blood were compared before and 1 week after surgery in burn sepsis group;receiver operating characteristic (ROC) was used to analyze the sensitivity and specificity.Results The differences of neutrophil CD64 and CRP levels in peripheral blood were statistically significant in three groups (P<0.05).Neutrophil CD64 and CRP levels in peripheral blood in burn sepsis group were significantly higher than those in burn local infection and burn without infection groups, while the levels in burn local infection group were significantly higher than those in burn without infection group (P<0.05).After treatment for 1 week, neutrophil CD64 and CRP levels in peripheral blood were significantly decreased than those before surgery in burn sepsis group (P<0.05).Receiver operating characteristic (ROC) curve area comparison showed Y(0.943)>CRP(0.910)>CD64(0.926);new variables Y of sensitivity and specificity was better than neutrophil CD64 and CRP in peripheral blood.Conclusion Infection degree of burns patients can be detected by neutrophil CD64 and CRP levels in peripheral blood in clinic, and the levels can provide reference for evaluating the diagnosing and treating for burns infection.