Effects of Different Hemodialysis Ways on Serum Folic Acid and Vitamin B12 Levels of Patients with Chronic Renal Failure

YAO Xiang-fei; WEI Qiao-ning

doi:10.3969/j.issn.1002-3429.2017.05.025

Abstract：Objective To investigate effects of different hemodialysis ways on serum folic acid and vitamin B12 levels of patients with chronic renal failure (CRF).Methods A total of 90 CRF patients admitted during January 2014 and March 2015, who were met entering and precluding standard, were selected and divided into continuous hemodialysis group (n=30), peritoneal dialysis group (n=30) and non dialysis group (n=30), and other 30 healthy people taking medical examination at the same period were selected as control group.Levels of serum folic acid and vitamin B12 levels were compared in four groups, and incidence rates of low serum folic acid and vitamin B12 in the three treatment groups were compared.Results There were significant differences in serum folic acid and vitamin B12 levels between control group and treatment CRF 3 groups (P<0.05).Serum folic acid and vitamin B12 levels in continuous hemodialysis and peritoneal dialysis groups were significantly lower than those in control group and non dialysis group (P<0.05);the levels in continuous hemodialysis group were significantly higher than those in peritoneal dialysis group (P<0.05).The differences in incidence rates of low serum folic acid and low vitamin B12 among treatment CRF 3 groups were statistically significant (P<0.05);the incidence rates in continuous hemodialysis and peritoneal dialysis groups were significantly higher than those in non dialysis group (P<0.05).Conclusion Both Continuous hematodialysis and peritoneal dialysis can decrease levels of serum folic acid and vitamin B12 of CRF patients, and continuous hematodialysis is better than peritoneal dialysis, and it is more suitable for CRF patients than peritoneal dialysis.