Relationship Between Helicobacter pylori and A and Atherosclerotic Cerebral Infarction

LV Jian-meng; YUAN Jie; LEI Qi; PAN Ya-juan; SONG Yun-zhang; YANG Qian

doi:10.3969/j.issn.1002-3429.2017.04.028

Abstract：Objective To investigate the relationship between Helicobacter pylori (HP) cytotoxin associated protein A (CagA) and atherosclerotic cerebral infarction.Methods From June 2015 to November 2016 in our hospital 65 cases of patients with cerebral infarction as the research object, 65 patients according to carotid artery plaque positive cases divided into carotid artery plaque in patients with cerebral infarction male positive group (observation group, n=35), cerebral infarction and non carotid artery plaque group (control group, n=30).At the same time, 30 healthy persons were selected as control group.The positive rate of CagA-HP-IgG antibody was compared between the three groups, and the correlation between the carotid artery lesions and serum CagA-HP-IgG antibody in the observation group was analyzed, and the diagnostic value of serum CagA-HP-IgG antibody was analyzed.Results The observation group positive rate of serum CagA-HP-IgG antibody was 62.9%;the control group of serum CagA-HP-IgG antibody positive rate of 40.0%;the positive rate of serum CagA-HP-IgG antibody was 23.3% blank control group;three serum CagA-HP-IgG antibody positive rate difference significantly (P<0.05).The Pearson correlation test showed that the carotid artery lesions in the observation group were positively correlated with the level of serum CagA-HP-IgG antibody (r=0.745, P=0.024).The sensitivity and specificity of serum CagA-HP-IgG antibody in the diagnosis of carotid artery lesions were 90.5% and 88.7%, respectively.The area under the ROC curve was 0.938 (95% CI:0.882,0.995).Conclusion CagA-HP-IgG may can be used as a predictive method for early carotid artery disease in patients with atherosclerotic cerebral infarction.