A Case Report of Autoimmune Hemolytic Anemia Misdiagnosed as Hereditary Spherocytosis
XIE Fei
HONG Ping
ZHOU Lin
CAI Bin
LEI Lei
CHEN Ruo-hua
Abstract：Objective To investigate clinical characteristics, misdiagnosed causes and preventive measures of autoimmune hemolytic anemia (AIHA).Methods Clinical data of one AIHA patient misdiagnosed as having hereditary spherocytosis was retrospectively analyzed.Results A 8-years-old patient was admitted for ochrodermia, tea-colored urine for 2 months and aggravation for 1 month.He was misdiagnosed as having hereditary spherocytosis after examinations such as red blood cell morphology examination, Coomb's test and hemolysis test in other hospital, and was discharged after treatment of blood transfusion, and was going to undergo splenectomy.AIHA was confirmed after positive results of rechecking Coomb's test by indirect and direct methods combined with hemolytic anemia in our hospital.The patient was treated with blood transfusion, immunoglobulin supplement and immunosuppression, and was discharged after having normal hemoglobin level.Conclusion Both AIHA and hereditary spherocytosis show hemolytic anemia, and differential diagnosis is mainly based on Coomb's test, but negative result of one time Coomb's test can not exclude AIHA, and therefore clinicians should give Coomb's test for many times for suspected children, and related gene test of heritage erythrocyte membrane diseases can be performed to accurately diagnose and treat if the condition is permissibility.
Keywords：AnemiahemolyticautoimmuneChildMisdiagnosisSpherocytosishereditary
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 52-54 )