A Case Report and Literature Review of 3 Misdiagnosed Patients with Adult-onset Still's Disease Associated by Abnormal Liver Function
ZHAO Song-qi
QIAN Yuan-yu
MENG Qing-yi
Abstract：Objective To investigate clinically atypical manifestations of adult-onset Still's disease (AOSD) to decrease misdiagnosis and mistreatment.Methods Clinical data of 3 patients with AOSD associated by abnormal liver function was retrospectively analyzed, and related literature was reviewed.Results All the 3 patients visited doctors for fever of undetermined origin and abnormal liver function, and were misdiagnosed as having drug-induced liver injury and (or) acute hepatitis and (or) liver abscess, but the patients' conditions did not improve after using lots of antibiotics and hepatic protectant medicines.After being transferred to our hospital, AOSD was confirmed according to clinical symptoms and medical examination results.Patients' conditions turned better after glucocorticoid treatment.All patients had no fever again with normal liver function during follow-up.Conclusion The abnormal liver function can be one of the features of part of the ASOD patients.Clinicians should consider possibility of AOSD for patients with the clinical manifestations of fever, joint pain, rash, sore throat, liver spleen lymphadenovarix, increased blood leukocytes, neutrophil granulocytes and ferroprotein and abnormal liver function have no effect after lots of antibiotics treatment, and the possibilities of infection, tumour or rheumatic immunologic diseases are excluded.
Keywords：Still diseaseadult-onsetFever of unknown originMisdiagnosisDrug-induced liver injuryHepatitisLiver abscess
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 31-35 )