Clinical Effects of Different Doses of Ulinastatin in Treatment of Patients with Mild and Moderate ARDS
DU Quan-sheng
YIN Gang
HE Cong
FU You
LONG Ling
SHEN Li-min
ZHAO He-ling
Abstract：Objective To observe clinical effects of different doses of Ulinastatin in treatment of patients with mild and moderate acute respiratory distress syndrome (ARDS).Methods A total of 60 patients with mild and moderate ARDS admitted during June 2014 and June 2016 were divided into control group (n=20),low dose group (n=20) and high dose group (n=20) according to random digits table.All patients received conventional therapy,and then low and high dose groups were added with 100,000U and 300,000U (TID) Ulinastatin by iv gtt (3/d for continuous 7d).Values of oxygenation indexes were recorded,and acute physiology and chronic health evaluation (APACHEⅡ) scores were detected before treatment and on the 8th d of treatment,and mortality on the 28thd after treatment,ICU mortality and the length of ICU stay were also calculated.Results There were no significant differences in oxygenation indexes and APACHEⅡ scores among the three groups before treatment (P>0.05).After treatment,oxygenation indexes were significantly increased,and APACHEⅡ scores were significantly decreased among three group (P<0.05);oxygenation indexes were significantly increased,while APACHEⅡ scores were significantly decreased in low and high dose groups compared with those in control group (P<0.05);oxygenation index was significantly increased (P<0.05),but there was no significant difference in APACHEⅡ score in high dose group compared with those in low dose group (P>0.05).Compared with those in control group,values of mortality on the 28thd after treatment,ICU mortality and the length of ICU stay were significantly decreased in low and high dose groups after treatment (P<0.05),but there were no significant differences in above values between low and high dose groups (P>0.05).Conclusion Ulinastatin can improve oxygenation condition,decrease APACHEⅡ scores and mortality on the 28th d and ICU mortality and shorten the length of ICU stay in patients with mild and moderate ARDS.
Keywords：Respiratory distress syndromeadultUlinastatinComparative Effectiveness Research
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 88-91 )