Expression and Clinical Significance of Serum miR-214 in Patients with Clear Cell Carcinoma of Kidney

HE Jiang-wei; Halmurat·Tusong; WANG Yu-jie; WANG Wen-guang

doi:10.3969/j.issn.1002-3429.2017.03.032

Abstract：Objective To investigate expression of serum miR-214 in patients with clear cell carcinoma of kidney and its clinical significance in diagnosis,therapy and prognosis judgement.Methods A total of 30 patients with clear cell carcinoma of kidney were selected as renal cancer group,and 30 healthy people taking medical examination at the same period were chosen as control group,and miR-214 expressions were detected by randomized method in control group,and the expressions were detected before surgery,1 week and 1 month after surgery in renal cancer group,and then expression differences and correlations with clinical indexes were compared between two groups.Results The differences of relative miR-214 expressions before and 1 week after surgery in renal cancer group and in control group were statistically significant (P<0.05).The differences of miR-214 expressions were statistically significant between before surgery and 1 month after surgery,and between 1 week after surgery and 1 month after surgery in renal cancer group (P<0.05).The differences of miR-214 expressions were not statistically significant between before and 1 week after surgery in renal cancer group,and between 1 month after surgery in renal cancer group with in control group (P=0.318,P=0.383).Diagnostic test was performed by using receiver operating curve (ROC),and area under curve (AUC) was 0.858 [95%CI (0.756,0.960),P<0.05].The best diagnostic point,sensitivity and specificity were 2.91,80.0% and 90.0% respectively according to Youden index.Conclusion Expressions of serum miR-214 in patients with clear cell carcinoma of kidney have correlation with clear cell carcinoma of kidney,and therefore it can be used as a potential molecular marker.