A Study on Proliferation and Apoptosis of Pregnancy Tissues in Early Recurrent Spontaneous Abortion Patients
SUN Li
CHEN Lin
MA Ji-hong
Abstract：Objective To analyze proliferation and apoptosis conditions of pregnancy tissues( villi nutrient and de-cidua cells)in early recurrent spontaneous abortion( RSA)patients and to investigate the possible pathogenic mechanisms. Methods A total of 60 early RSA patients within 12 weeks of pregnancy( group A),medical abortion of 60 patients( group B)and 60 patients with induced abortion( group C)during January 2014 and December 2015 were recruited in this study. In three groups,apoptosis conditions of villi nutrient cells and decidual cells were detected by using DNA in situ end labeling method,and then expressions of placenta growth factor( PLGF ) and apoptosis related factors Caspase-3 were detected by using immunohistochemical staining method. The correlation between PLGF and Caspase-3 expressions was analyzed in group A. Results In group A,values of apoptosis index(AI)of villi and decidual cells were significantly higher(P﹤0. 01);ex-pressions of Caspase 3 and PLGF were significant lower(P﹤0. 01),and Caspase-3 expressions in villi and decidua cells were significantly higher than those in group B and C(P﹤0. 05). Correlation analysis showed that Caspase-3 and PLGF expres-sions were negative correlation in group A(r﹦ -0. 891,P﹦0. 004;r﹦ -0. 927,P﹦0. 001). Conclusion The pathogen-esy of early RSA may be related to proliferation disorder of villi and decidua cells induced by PLGF poor expression and exces-sive apoptosis of villi and decidua cells induced by increasing Caspase-3 expression.
Keywords：AbortionhabitualPregnancy trimesterfirstVilliDeciduaCell proliferationApoptosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-97 )