Heparin-induced Thrombocytopenia Combined with Venous Thrombosis of Lower Limbs and Cerebral Hemorrhage after PCI Surgery
CHENG Jing-hua
MIN Yu-rong
PENG Yong-ping
GONG Jian-bin
Abstract：Objective To improve the diagnosis and awareness of heparin-induced thrombocytopenia( HIT)in order to avoid misdiagnosis and mistreatment. Methods Clinical data of a patient with low molecular HIT was retrospectively ana-lyzed,and relative literature was reviewed. Results The patient with acute inferior wall right ventricular myocardial infarction received Aspirin,Ticagrelor,Eptifibatide and low molecular heparin treatments after undergoing percutaneous coronary inter-vention( PCI ). Widely peripheral venous thrombosis was found on postoperative 15 days. Anticoagulation treatment was changed to 75 mg Clopidogrel with once daily by orally and 4000 U low molecular heparin by one time for every 12 h by subcu-taneous injections,and then right occipital hemorrhage was found,and platelet count was rapidly decreased more than 50﹪ 2 days later. The patient was diagnosed as having type Ⅱ HIT according to the 4Ts score standard. The platelet count gradually improved when the anticoagulant drugs were changed to Fondaparinux Sodium and( or)Dabigatran ester. The platelet recov-ered to normal 7 months later. Conclusion HIT is rare and latent,so clinicians should highly suspect HIT for patients with decreasing platelet count after anticoagulant treatment with containing heparin drugs. Clinical evaluation and medical examina-tions should be performed early so as to confirm diagnosis and treatment as early as possible.
Keywords：HeparinDrug toxicityThrombocytopeniaVenous thrombosisCerebral hemorrhage
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 69-72 )