A Report of One Misdiagnosed Patient with Giant Ovarian Juvenile Granulosa Cell Tumor and a Literature Review

LIU Chang; JIN Yue-mei; LIU Shan-shan; WANG Xiu-xiu; WANG Qu-yuan; SHAO Yan-ping

doi:10.3969/j.issn.1002-3429.2017.01.014

Abstract：Objective To investigate clinicopathologic features,diagnosed key points and misdiagnosed causes of gi-ant ovarian juvenile granulosa cell tumor( JGCT)in order to improve the level of differential diagnosis. Methods Clinical data of 1 misdiagnosed patient with giant ovarian JGCT was retrospectively analyzed,and relevant literature was also reviewed. Results A 20-year-old female patient was admitted for abdominal bulge accompanied by abdominal distension,loss of appe-tite,urinary frequency and menstrual disorders. The whole abdomen CT suggested that it was cystic occupying lesions in ab-dominal and cavitas pelvis. The cancer antigen-125(CA125)was 95. 50 U/ml,and CA199 was 8. 4 U/ml,and carcinoem-bryonic antigen was 0. 78 ng/ml. Preoperative diagnosis was abdominal mass. A gray cystic mass was found by exploratory laparotomy,and its bottom was connected with the left tuba uterinauterine. Ovarian sex cord stromal tumor was suspected by rapidly pathological diagnosis during the operation. Resection of the left ovarian mass and a wedge biopsy of the right ovary were performed,and the postoperative pathological diagnosis was ovarian JGCT. All patients received postoperative chemother-apy with Bleomycin+Etoposide+Platinol( BEP)for 3 courses. The menstruation returned to normal without tumor recurrence during 4 months of follow-up. Conclusion Ovarian JGCT is rare,and it is easily misdiagnosed in the preoperative and intrao-perative diagnosis. Diagnosis can be confirmed by pathological examination and immunohistochemical staining.