Comparison between SUVmax and MTV in Prediction of Effectiveness of Neoadjuvant Chemotherapy in Treatment of Breast Cancer Tumor

HOU Li-juan; ZHANG Xi-ping

doi:10.3969/j.issn.1002-3429.2016.12.036

Abstract：Objective To observe differences of Fluoro-deoxyglucose F18 (18 F-FDG PET-CT) maximum standard uptake value( SUVmax) and mean tumour volume ( MTV) in prediction of effectiveness of neoadjuvant chemotherapy in treat-ment of breast cancer tumor. Methods A total of 63 patients with breast cancer between January 2014 and September 2015 were recruited in this study. 18F-FDG PET-CT imaging was performed before, at the end of the 1st and 2nd courses of neoadju-vant chemotherapy, and change rates of SUVmax (⊿SUVmax1%,⊿SUVmax2%) , and MTV change rates on the basis of SUV equal to 1. 5 (⊿MTV1%,⊿MTV2%) and 2. 5 (⊿MTV1′%,⊿MTV2′%) were calculated and compared. Results There were 32 patients ( effective group) and 31 patients( ineffective group) after the end of neoadjuvant chemotherapy. There were no significant differences of⊿MTV1%,⊿MTV2% and⊿MTV1′% between the two groups (P>0. 05), while values of⊿MTV2′%,⊿SUVmax1% and⊿SUVmax2% in effective group were significantly larger than those in ineffective group (P<0. 05). Compared with those in ineffective group, there were no significant differences in values of ⊿MTV1%,⊿MTV2%, ⊿ MTV1′% and ⊿ MTV2′% of the patients whose tumor diameter more than or equal to 2. 5cm and⊿MTV1%,⊿MTV1′% and ⊿MTV2′% of the patients whose tumor diameter less than 2. 5 cm in effective group before chemotherapy (P>0. 05);while⊿MTV2% value of the patients whose tumor diameter less than 2. 5 cm before chemothera-py in effective group was significantly higher (P<0. 05). Conclusion SUVmax and MTV have a certain effect in prediction of effectiveness of neoadjuvant chemotherapy with similar effect in treatment of breast cancer tumor.