Clinical Significances of Ngb, BDNF and MBP Detection in Patients with Acute Cerebral Infarction

XIA Cui-ping

doi:10.3969/j.issn.1002-3429.2016.12.032

Abstract：Objective To observe level changes of neuroglobin (Ngb), brain-derived neurotrophic factor (BDNF) and myelin basic protein ( MBP) in patients with acute cerebral infarction, and the relationship between severity of pathogenet-ic condition and prognosis. Methods A total of 126 patients with acute cerebral infarction admitted during January 2012 and December 2015 were selected as cerebral infarction group, and 30 healthy persons taking physical examination at the same pe-riod were selected as control group. Changes of serum Ngb, BDNF and MBP levels were compared in two groups, and relation-ships between each index and degree of cerebral nerve of functional injury, infarct size and prognosis and the relationships a-mong indexes were observed. Results Compared with those in control group, Ngb and MBP levels were significantly in-creased (P<0. 01), while BDNF level was significantly decreased in cerebral infarction group (P<0. 01). In cerebral in-farction group, serum Ngb and MBP levels were increased (P<0. 01), while BDNF level was decreased with aggravated de-gree of neurological function and increased infarct area (P<0. 01). In cerebral infarction group, Ngb and MBP levels were significantly decreased (P<0. 01), while BDNF levels were significantly higher in patients with good prognosis compared with those of patients with poor prognosis ( P <0. 01 ) . Serum BDNF levels were negatively correlated to Ngb and MBP levels (r= -0. 654, P<0. 05;r= -0. 768, P<0. 05), while Ngb levels were positively correlated to MBP levels in patients with acute cerebral infarction (r= 0. 622, P<0. 05). Conclusion Ngb, BDNF and MBP are involved in pathogenesy and devel-opment of acute cerebral infarction, and therefore it is significant to detect the levels for evaluation of pathogenetic condition and prognosis.