Effect of Preoperative Blood Platelet Infusion on Prognosis of Cirrhosis Portal Hypertension Syndrome Patients be-fore Devascularization

ZHANG Ji-zhong; HU Liang; YI Yong-xiang

doi:10.3969/j.issn.1002-3429.2016.12.030

Abstract：Objective To investigate the effect of preoperative blood platelet infusion on prognosis of cirrhosis portal hypertension ( PTH) syndrome patients before surgery in order to provide a reference for evaluating of devascularization opera-tion. Methods A total of 78 cirrhosis PTH syndrome patients admitted during July 2011 and June 2012. were divided into observation group (n=39) control group (n=39) according to random digits table method. All patients received devascular-ization, while the observation group was added with preoperative transfusion of apheresis platelet 10 U. Changes of platelet count during peroperative period, daily peritoneal volume, usage of blood products and mortality at postoperative 7th d were compared between two groups. Results Postoperative values of platelet count were significantly increased compared with those before surgery in two groups (P<0. 05). Compared with those in control group, in observation group, values of platelet count on postoperative 1st h and 24th h were significant increased; values of postoperative 7 d daily peritoneal volume, red blood cell suspension, human albumin and platelet dosage were significantly lower (P<0. 05). In observation group, platelet recovery rate (PPR) were (102. 37 ± 62. 65)% and (106. 39 ± 54. 52)%, and corrected count increment (CCI) of postop-erative platelet were up to (29. 05 ± 16. 28)% and (31. 29 ± 12. 33)% respectively 1 h and 24 h after platelet transfusion than those in control group (P <0. 05). There were 2 death cases (5. 13%) in observation group and 3 death cases (7. 69%) in control group after the surgery, but the difference was not statistically significant (P>0. 05). Conclusion Preoperative blood platelet infusion can reduce incidence rate of acute hemorrhagic of patients with cirrhosis PTH after devas-cularization, and reduce dosage of blood products.