Malignant Peripheral Nerve Sheath Tumor Misdiagnosed as Diabetic Foot:a Report of 2 Cases
WANG Lu-ning
YANG Cai-zhe
WU Shi-bai
Abstract：Objective To improve understanding of clinicians about malignant peripheral nerve sheath tumor ( MPNST) in order to reduce misdiagnosis and mistreatment. Methods Clinical data of 2 MPNST patients misdiagnosed as having diabetic foot was retrospectively analyzed, and related literature was reviewed. Results The 2 patients were admitted for foot ulcerate and elevated level of blood sugar. The 2 patients were treated as soft-tissue infection of foot skin and paronych-ia with poor effectiveness in other hospitals, and elevated level of blood sugar were found, but protracted course of disease in wound surface was found after hypoglycemic therapy. Medical examinations such as vascular ultrasound for lower extremity, electromyogram and electrocardiogram showed that no obviously lesions of diabetic peripheral vasculopathy and nerves, and blood-glucose level was controlled well. The histopathological examination for wound surface tissues showed S-100( +), and then MPNST was confirmed. One patient refused further treatment and discharged with losing follow-up; no abnormal was found in another patient by ultrasound for surface lymph nodes, abdomen and pelvic cavity, cranial computed tomography and total body of bone scanning, and toe amputation was performed, and then the patient was discharged after wound healing. No indisposition was told during 1 year of follow-up. Conclusion MPNST in foot is rare, and therefore clinicians should improve awareness and take histopathologic examinations as early as possible to confirm diagnosis and treatment so as to avoid or de-crease misdiagnosis and mistreatment.
Keywords：Nerve sheath neoplasmsMisdiagnosisDiabetic foot
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 45-48 )