Curative Effect of Hyperbaric Oxygen Therapy Combined with Salvianolate in Treatment of Diabetic Perineuropathy

CHEN Ze-xiang; LU Lei; ZHAO Yu-wu

doi:10.3969/j.issn.1002-3429.2016.11.031

Abstract：Objective To observe curative effect of hyperbaric oxygen therapy combined with Salvianolate in treat-ment of diabetic perineuropathy ( DPN) . Methods A total of 140 patients with type 2 DPN were divided into hyperbaric oxy-gen group (n=70) and conventional group (n=70) by random digits table method. Conventional group received conventional treatments such as Salvianolate, while hyperbaric oxygen group was added with hyperbaric oxygen therapy on the basis of con-ventional treatments. In two groups, scores of neurological symptoms, neurological total symptom score ( TSS) and Michigan neuropathy screening instrument ( MNSI) before and 7 and 14 d after treatment were analyzed and compared, and incidence rates of adverse reaction were also observed at the same time. Results Before treatment, the differences in scores of neuro-logical symptom , neurological TSS and MNSI were not statistically significant(P>0. 05). In hyperbaric oxygen group, scores of neurological symptom , neurological TSS and MNSI 7 and 14 d after treatment were significantly decreased than those before treatment (P<0. 01);scores of neurological symptom , neurological TSS and MNSI in hyperbaric oxygen group 7 and 14 d af-ter treatment were significantly decreased than those in conventional group (P<0. 01). In hyperbaric oxygen group, scores of neurological symptom , neurological TSS and MNSI 14 d after treatment were significantly decreased than those 7 d after treat-ment (P<0. 05). During the hyperbaric oxygen treatment, 5 patients complained earache, and then earache was self-relieved during the treatment process without any special therapy or stopping therapy. Conclusion Hyperbaric oxygen therapy com-bined with Salvianolate has well curative effect in treatment of diabetic perineuropathy with less adverse reactions.