System Evaluation of Efficacy and Safety of Low-Molecular Weight Heparin for Mild-to-moderate Active Ulcerative Colitis
ZHOU Xu-xian
FANG Yan-fei
WANG Bing-fang
Abstract：Objective To evaluate the efficacy and safety of low molecular weight heparin ( LMWH) for mild-to-mod-erate active ulcerative colitis ( UC) . Methods The Cochrane Library, Pubmed, EMbase, CNKI, VIP Database and CBM Database were searched, and the retrieval time was from the establishment of the library to January 2015. Two reviewers inde-pendently retrieved literatures according to the inclusion and exclusion criteria, assessed the methodological quality of included trials and extracted data. Then the data analysis was performed by RevMan 5. 3 software, and subgroup analysis and sensitivity analysis were performed at the same time. Results Six studies of randomized controlled trial ( RCT) literatures involved in 447 cases of mild-to-moderate active UC, which included the test group (n=223) and the control group (n= 224). The re-sult of meta-analysis showed that the total efficacy rate of test group was better than that of control group [RR=1. 18, 95%CI (1. 05,1. 33), P=0. 005];the complete remission rate of test group was better than that of control group [RR=1. 64, 95%CI(1. 32,2. 04), P<0. 00001]. There was no significant difference in incidence of adverse reactions [RR=0. 76, 95%CI (0. 48,1. 21), P=0. 25] between the two groups. Conclusion LMWH for patients with mild-to-moderate active UC is ef-fective with no significant adverse effects.
Keywords：ColitisulcerativeHeparinlow-molecular-weightTreatment outcomeMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 89-95 )