Vancomycin Associated Acute Kidney Injury:A Case Report and Literature Review
YANG Meng-meng
ZHOU Fei-hu
ZHAO Yan
PAN Liang
WANG Li
HU Xin
KANG Hong-jun
Abstract：Objective To discuss the clinical characteristics , prophylaxis and therapy of Vancomycin associated a-cute kidney injury in order to improve the understanding about Vancomycin associated acute kidney injury .Methods Clinical data of a patient admitted to our department for Vancomycin associate acute kidney injury was retrospectively analyzed and re -lated literature was reviewed .Results The patient was admitted to the department of orthopedics in our hospital for congenital hip dislocation on the right side and right hip osteoarthritis .He received a total hip artificial joint replacement underwent right proximal femoral osteotomy surgery , which was accomplished successfully under epidural anesthesia , and the preoperative liver and renal functions were at normal levels .Then Vancomycin 1 g bid combined with Ceftriaxone 2 g qd were given for anti-in-fection and Rivaroxaban tablets of 5 mg qd used as anticoagulant .On day 3, the patient developed clinical symptoms including oliguria, thirst, nausea, vomiting and irritability.Concentrations of serum creatinine and urea nitrogen were simultaneously in -creased significantly .Due to these complications ,the diagnosis was drug-induced acute kidney injury , antibiotics and anticoag-ulants were discontinued and Vancomycin level was much higher than normal .On postoperative day 4, the patient was trans-ferred to department of critical care medicine because his condition became worse .With continous renal replacement therapy ( CRRT) and other symptomatic treatment , the patient recovered gradually .Conclusion Clinicians should be vigilant about nephrotoxicity in the process of application of Vancomycin .If the symptoms of acute kidney injury occur without explainable reasons, its side effects of nephrotoxicity should be taken into consideration .Monitoring concentration of the drug , discontinu-ing infusion in time and initiating CRRT as early as possible are effective measures to recover renal function of the patients .
Keywords：VancomycinDrug toxicityAcute kidney injury
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 63-68 )