Changes of Thyroid Hormone in Acute Cerebral Infarction Patients with Non-thyroid Illness Syndrome and Their Im-pact on Neurological Impairment
LUO Bi-jun
KONG Ming-hao
Abstract：Objective To observe the levels of thyroid hormone in acute cerebral infarction patients with non-thyroid illness syndrome, and their impact on the thyroid function after intervention with Thyroxine tablets. Methods 103 patients with acute cerebral infarction, admitted during January 2010 and January 2015, were selected as cerebral infarction group, and 30 pa-tients with normal thyroid function were as normal group. The thyroid hormone levels before and after treatment in cerebral in-farction group were compared with that of the control group. The levels of thyroid hormone were compared according to cerebral infarction area ( large, middle and small) and the national institutes of health stroke scale ( NIHSS) ( mild, moderate, and se-vere) . 74 cases with low thyroid function were as low group, and the changes of NIHSS and daily living ( ADL) scores were ob-served before and after hormone therapy between cerebral infarction group and normal group. Results The levels of triiodothyro-nine (T3), 3 free triiodothyronine (FT3), 4 iodine thyronine (T4), free 4 iodine thyronine (FT4) and thyroid hormone stimu-lating hormone ( TSH) decreased in cerebral infarction group, compared with those of control group ( P<0. 01 ) , and as the nerve injury degree and cerebral infarction area increased in cerebral infarction, and the levels of T3, FT3, T4, FT4 and TSH decreased significantly (P<0. 01). After treatment, the levels of those increased more than those after treatment (P<0. 01), but there was no significant difference between those after treatment and in control group (P>0. 05). Before treatment, the NIHSS scores were not significantly higher in hypothyroidism group than in normal thyroid function group, while the ADL scores were significantly lower than those in normal thyroid function group (P<0. 01), after treatment, the NIHSS and ADL scores showed no statistically significant difference between hypothyroidism group and normal thyroid function group (P>0. 05). Con-clusion The thyroid dysfunction plays an important role in the development of acute cerebral disease, and corrected thyroid dys-function can improve the treatment effect and prognosis in patients with cerebral infarction.
Keywords：InfarctionThyroid functionPrognosisThyroxine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 96-99 )