Effect of Enteral Immune Micro-ecological Nutrition Support on Liver Damage in Patients with Liver Cancer After Hepatectomy

HUANG Zhi-qing; ZHANG Cheng-hua; SHI Jian-she; DU Zhen-shuang; CHEN Shu-lan; LIANG Xiao-hua

doi:10.3969/j.issn.1002-3429.2016.02.029

Abstract：Objective To investigate the effect of enteral Immune micro-ecological nutrition support ( EIN) on liver damage in patients with liver cancer after hepatectomy. Methods 80 patients with liver cancer during April 2010 and April 2015 were selected and were randomly divided into EIN group and early enteral nutrition ( EN) group ( n=40 in each group) . Patients who suffered a seizure or refused the treatment were ruled out of the study. Eventually EIN group had 37 cases and EN group had 36 cases in this study. Both groups were given EN, and on the basis of EN, EIN group was given EIN, nutritional support for 1 week. The anus exhaust time and nutrition complications after operation were observed. Preoperative and postop-erative 2 days and postoperative 8 days, liver function detection, endotoxin, tumor necrosis factor alpha ( TNF alpha) , inter-leukin 6 (IL6) were compared. Results EIN group had 5 cases of postoperative adverse reactions (13. 5%) while EN group had 7 cases (19. 4%), and there was no statistically significant difference (P>0. 05). Postoperative exhaust time of EIN was shorter than that of EN group (P<0. 05). Preoperative and postoperative 2 days, liver function and blood endotoxin, IL-6 level had no statistical significance in the two groups (P>0. 05). Postoperative 8 days, liver function of EIN group was superior to that of EN group (P<0. 001). TNF-α2 days after surgery was higher than that of the two groups. The elevated levels of EIN were lower than that of EN group (P<0. 001). Blood endotoxin and TNF-αand IL-6 of EIN group postoperative 8 days were significantly lower than that of EN group (P<0. 001). Conclusion EIN can protect intestinal mucosal barrier function, reduce bacteria and endotoxin translocation, adjust the immune function, reduce systemic inflammatory reaction, and therefore reduce liver damage of hepatocellular carcinoma patients after hepatectomy.