Correlation Analysis of Serum Golgi Protein 73 with HBV-related Decompensated Cirrhosis of Liver Function
HUANG Jin-fa
XU Zheng-ju
PAN Xing-nan
XU Tao
WEI Mei-juan
CHEN Yu-xia
ZHENG Lian-qiu
Abstract：Objective To investigate the serum Golgi protein 73 (GP73) expression and the compensated stage of HBV-related decompensated cirrhosis ( HLC) in correlation of liver function of patients. Methods 150 patients of HBV-re-lated decompensated cirrhosis patients during January 2012 and March 2014 were selected. All patients were treated with ser-um ELISA, and enzyme-linked immunosorbent assay was used to detect GP73 levels in patients. According to the GP73 level, 150 patients were divided into high GP73 group (82. 50 μg/L), medium GP73 group (57. 98 ~ 82. 50 μg/L) and low GP73 group ( < 57. 98 μg/L). Serum alanine aminotransferase ( ALT), aspartic aminotransferase ( AST), and total bilirubin ( TBIL) level in the three groups were detected and compared. Correlation analysis of liver function and GP73 level in HLC patients was carred out. Results AST, TBIL level content of high GP73 patients were significantly higher than low-GP73 and medium-GP73 groups, AST, TBIL level content of medium GP73 groups were significantly higher than low-GP73 group, and the differences were statistically significant (P<0. 05). Serum GP73 levels of gradually increased with in crease of ALT, AST, TBIL content and ALT, AST, TBIL content showed a positive correlation ( r =0. 632, r =0. 646, r =0. 726; P<0. 001). There was no statistically significant difference of the HBV-DNA content in the three group (P>0. 05). Conclusion Serum GP73 level is closely related to liver damage of HLC patients. It is one of the important indicators in the diagnosis of HLC, but has nothing to do with the level of HBV replication.
Keywords：Serum Golgi protein 73Hepatitis B virusCirrhosisLiver function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 99-101 )