Assessment of the Value of Arterial Elasticity Measurement in Hypertensive Disorders in Pregnancy for Patients with Poor Prognosis

CHEN Xiang-yi

doi:10.3969/j.issn.1002-3429.2015.12.029

Abstract：Objective To investigate the adverse prognostic value in arterial elasticity coefficient (compliance, C) for hypertensive disorders in pregnant ( HDCP) patient assessment. Methods Clinical data of related risk factors of 49 cases of maternal HDCP and prospective continuity incorporated during January 2013 and July 2014 in obstetrics and gynecology ad-missions of pregnancy-induced hypertension ( PIH ) were collected and according to follow-up endpoint progress into severe preeclampsia ( SP) , the patients were divided into pregnancy-induced hypertension of ( PIH) group and SP group. Early de-tection indicators of the two groups were compared and analyzed for differences, and Logistic regression analysis was used to further extract independently sensitive indicators, draw the corresponding index of receiver operating characteristic ( ROC) curve and calculate the area under the curve ( AUC) . Results The patients of SP group of the incidence of gestational age, family history of hypertension, accounting, mean arterial pressure (MAP), body mass index, platelet, plasma fibrinogen (FIB), cystatin endostatin C (CysC), lysophosphatidic acid (LPA), albumin (ALB), small artery elasticity (C2) of SP group showed statistically significant differences (P<0. 05), when compared with that of PHI group, multivariate Logistic re-gression analysis of MAP, FIB, CysC, LPA, C2, the 5 indicators were independent, and sensitive HDCP poor prognosis fac-tors, including poor prognosis for determining C2 AUC 0. 730, ROC curve analysis obtained the best assessment predicted in-tercept point threshold value C2 8. 75 ml/mmHg × 100. MAP, FIB, CysC, LPA, the 4 indicators of poor prognosis determina-tion HDCP AUC 0. 830, to 0. 854 after adding C2 AUC were jointly determined. Conclusion C2 levels can be used as an in-dependent index to judge PIH sensitive factors of poor prognosis, the C2 system included in HDCP and used in clinical inter-vention for pregnant women at high risk is of significant value.