Correlation Analysis between the HMGB1 Concentration of Patients with Severe Trauma and Injury Severity Score and Prognosis
LUO Tao
YI Xiang-ying
MA Ying-xia
LIU Hong-wu
LI Jing-fei
DUAN Xing-yuan
Abstract：Objective To discuss the correlation between the HMGB1 concentration changes and injury severity scores of patients with severe trauma and the prognosis. Methods 80 cases of patients with severe trauma admitted to our hospital during January 2009 and January 2013 according to the prognosis were divided into survival group ( n=48 cases) and mortality group ( n=32 cases) . Peripheral blood concentration of HMGB1 and HMGB1 mRNA and ISS scores evaluation in the two groups of patients were detected on 1st d, 3rd d, 5th d, 7th d, 9th d after admission, and viscera damage related bio-chemical indicators was detected when the concentration of HMGB1 changed. The receiver-operating characteristic ( ROC) curve was used to analyze the prognosis value in evaluation of HMGB1 in the patients with severe trauma, spearman correlation analysis was used to analyze the correlation of HMGB1 level and the ISS score. Results The concentration of HMGB1, mRNA HMGB1 and ISS scores in the two groups on 1 st d upon admission showed no statistically significant differences between the two groups (P>0. 05). On the 3rd d, 5th d, 7th d, 9th d upon admission, the concentrations of HMGB1 and HMGB1 mR-NA and ISS scores of the mortality group were higher than that of survival group, and the differences were of statistical signifi-cance (P<0. 05 or P<0. 01). HMGB1 concentration of the survival group began to decrease on 7th d, the concentrations of serum alanine aminotransferase ( ALT) , aspartate transaminase ( AST) , blood urea nitrogen ( BUN) , creatinine ( Cr) , serum creatine kinase ( CK) , creatine kinase isoenzyme ( CK-MB) in the mortality group were obviously higher than that of the sur-vival group (P<0. 05), but PaO2 was significantly lower than that of the survival group (P<0. 05). ROC curve showed that HMGB1 had ideal sensitivity and specificity in assessing the prognosis of severe trauma and the Spearman correlation analysis showed that HMGB1 levels had positive correlation with the ISS scores. Conclusion The dynamic monitoring of HMGB1 has certain clinical significance in predicting the prognosis of patients with severe traumawhile and the HMGB1 levels has positive correlation with ISS scores.
Keywords：HMGB1 proteinWound and injuryPrognosisInjury severity score
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 99-103 )