Application Effect and the Safety Evaluation of Microbio Ecological Preparation in Biliary Intestinal Anastomosis during Perioperative Period
LIU Hui-fang
ZHANG Cheng-hua
AI Ye-qing
Abstract：Objective To investigate the application effect and the safety evaluation of microbio ecological prepara-tion ( MBP) in biliary intestinal anastomosis during perioperative period. Methods 67 patients admitted during March 2011 and March 2014 were chosen as research subjects. They were to undergo anastomosis. According to random number table method, the patients were randomly divided into observation group (34 cases) and control group (33 cases). The control group was given perioperative conventional interventions. Perioperative observation group, based on the treatment of conven-tional interventions, was given for intestinal MBP. The variation of gut bacteria counts, recovery condition after operation, the time of postoperative infection related index returning to normal, postoperative antibiotic consumption time, the incidence of complications and case fatality rate after operation of the two group 5 days before operation and 2 weeks after operation were ob-served. Perioperative adverse reactions of the two groups were also recorded. Results Bifidbacterium, lactobacillus, entero-coccus, total colony counts improved more significantly 2 weeks after operation than that 5 days before operation in observation group. In control group, bifidobacterium, lactobacillus, enterococcus counts were significantly lower than that 5 days before operation. In observation group, bifidobacterium, lactobacillus and enterococcus counts were significantly higher than that of the control group. The differences were statistically significant (P<0. 05). The exhaust time after operation, defecation time, hospitalization time, the time of postoperative infection related index returning to normal, antibiotics consumption time of ob-servation group were shorter than that of the control group. The differences were statistically significant (P<0. 05). The inci-dence rate of complications and case fatality rate after operation of the two groups were compared. There were no statistically significant differences (P>0. 05). During perioperative period, no obvious adverse reaction occurred in the two groups. Con-clusion In the bile of intestinal anastomosis, perioperative application of MBP can adjust the intestinal flora, promote postop-erative recovery, shorten the course of the disease, with better safety and a lower rate of infection.
Keywords：Microbio ecologicalpraeparatumAnastomosissurgicalPerioperative period
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 91-94 )