Retrospective Analysis of Efficacy and Safety between Different Administrations of Reteplase Via Venous Pump in Treatment of Acute Pulmonary Embolism
XIAO Ming
ZHANG Hua-yong
MA Lin
MA Na-na
WANG Tao
HOU Zi-long
SU Zi-de
Abstract：Objective To compare the clinical efficacy and safety between different administrations of domestic rete-plase via venous pump in thrombolysis of acute pulmonary embolism. Methods 49 patients with acute pulmonary embolism hospitalized in our center during January 2012 and April 2014 were retrospective analyzed and treated with reteplase. Among them, 17 patients received reteplase at a dose of 18 mg via venous pump in 2 hours;the other 32 patients were treated with re-teplase according to the traditional instruction, namely double intravenous injection with an interval of 30 minutes;in addition, 27 patients with acute pulmonary embolism were chosen as control group, who underwent urokinase thrombolysis according to guidelines, and then we observed the recanalization, hemorrhage reaction and 30-day mortality rate respectively. Results The recanalization rates, PaO2 and the mean pulmonary artery pressure before and after treatment of the three groups showed significant differences (P<0. 01). After treatment, thrombolysis efficient rate of group P was the highest and there was statis-tically significant difference compared with group T and control group. 30 d mortality rate of r-PA venous pump group was ze-ro, lower than that of the other two groups (25. 00% and 22. 22%, P<0. 05) and there was no significant difference in the hemorrhage reaction rates between the three groups (P>0. 05). Conclusion Patients with acute pulmonary embolism under-going treatment with domestic reteplase by pumping r-PA slowly can achieve similar effect with the traditional thrombolytic method and the hemorrhage and mortality rates are significantly decreased. It is a more effective and safer method in treating PE.
Keywords：ReteplasePulmonary embolismUrokinase-type plasminogen activatorInfusion pump
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 89-92 )