Efficacy and Safety of Intravenous Thrombolytic Therapy with Recombinant Human Tissue-type Plasminogen Kinase Derivatives (r-PA) and Recombinant Human Tissue Type Plasminogen Activator (rt-PA) for the Treatment of Acute ST Segment Elevation Myocardial Infarction:a Meta-analysis
LI Yan-jun
TANG Yan-Hong
Abstract：Objective To evaluate the efficacy and safety of recombinant human tissue-type plasminogen kinase de-rivatives and recombinant human tissue type plasminogen activator thrombolytic therapy in acute ST segment elevation myocar-dial infarction. Methods Such databases as PubMed, EMbase, the ISI Web of Knowledge Databases, CNKI, VIP and Wan fang were searched from their establishment to April 2014 for collecting the randomized controlled trials ( RCT) about r-PA versus rt-PA for the treatment of acute ST segment elevation myocardial infarction. Meta-analysis was performed using the Rev-Man5. 2 software. Results 14 studies involving 1375 patients were included. The results of meta-analysis showed that:com-pared with the rt-PA group, in r-PA group, recanalization rate after thrombolysis was higher [ RR=1. 17, 95% CI 1. 10-1. 25, P<0. 01], blood loss rate had no significant difference [RR=1. 06, 95% CI 0. 80-1. 41, P=0. 69], arrhythmia in-cidence had no significant difference [RR =0. 82, 95% CI 0. 65-1. 03, P =0. 08], re-infarction rate had no significant difference [RR=0. 48, 95% CI 0. 15-1. 58, P =0. 23], the mortality rate had no significant difference [RR =0. 67, 95% CI 0. 40-1. 12, P=0. 13]. Conclusion The efficacy of r-PA intravenous thrombolytic therapy for acute ST segment el-evation myocardial infarction is significantly better than rt-PA thrombolytic therapy and there is no significant difference in terms of safety at onset.
Keywords：Myocardial infarctionThrombolytic therapyRecombinant human tissue-type plasminogen kinase deriv-ativeRecombinant human tissue type plasminogen activatorMeta-analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 80-86 )