A Study on the Antibiotic Resistance of Staphylococcus to Clindamycin Induced by Erythromycin in the Alar Sub-re-gion of the Xinjiang Uygur Autonomous Region
HOU Xiang-ping
QIN Xu-hong
GONG He-jun
WEI Ce
Wang Li
LI Qiong
DAI Jin-hui
MENG Qing-yi
Abstract：Objective To understand the antibiotic resistance of Staphylococcus to clindamycin induced by erythro-mycin in the Alar sub-region of the Xinjiang Uygur autonomous region, and to guide the clinical selection of antibacterial drugs to avoid misdiagnosis. Methods Drug resistance of clinically isolated and identified 300 strains of Staphylococcus was detec-ted using K-B agar diffusion method, and then the D test method was used for detection of inducible clindamycin resistance in the erythromycin resistant Staphylococcus. Results ①The Staphylococcus sensitive to clindamycin was 38. 0% (114/300) and to erythromycin was 19. 7% (59/300), and clindamycin resistant strains were also resistant to erythromycin. ②The pro-portion of erythromycin and clindamycin resistant Staphylococcus aureus (69. 6%) was higher than that of coagulase negative staphylococcus (56. 6%), and the difference was significant (P=0. 031). ③The sensitive proportion of methicillin-resistant Staphylococcus aureus (MRSA) on clindamycin (21. 6%, 21/97) was significantly lower than that of methicillin resistant co-agulase negative staphylococcus (MRCNS;40. 9%, 63/154) with the significant difference (P=0. 002). ④Among the 55 Staphylococcus strains of erythromycin resistant and clindamycin sensitive, 39 strains were positive in D test (70. 9%, 39/55), while MRSA inducible clindamycin resistance rate was 85. 7% (18/21) and NRCNS was 76. 2% (16/21), and the difference was no significant (P=0. 452) induction clindamycin resistance rate of the two types of methicillin resistant Staphy-lococcus were also higher than that of sensitive strains correspondingly, with significant difference (all P<0. 05). Conclu-sion The antibiotic resistance for erythromycin and clindamycin in Alar area is different from different categories of Staphylo-coccus aureus, and nearly 2/3 of Staphylococcus strains have clindamycin resistance induced by erythromycin. D test can de-tect the pseudo-sensitivity of clindamycin in routine drug susceptibility test.
Keywords：Staphylococcus hominisErythromycinClindamycinDrug screening assayTherapeutic error
Publication Date：2015-01-01
Pages：5( 72-76 )