Research on 2010-2014 Chinese literature on Acute Kidney Injury Caused by Clindamycin
WANG Jun-feng
Abstract：Objective To investigate of clindamycin induced acute kidney injury ( acute kidney injury, AKI) , and to provide reference basis for rational use of drugs. Methods The adverse reactions of clindamycin and AKI or drugs were as the search type. CNKI during 2010 and 2015 about clindamycin leading to AKI was retrieved, and literature of a total of 23 ar-ticles was included. Summary and analysis of all the information were recorded in the Excel software. Results Clindamycin resulted in a total of 425 cases of AKI;primary diseases of the patients were upper respiratory tract infection, gastroenteritis, gingivitis, pharyngitis, bronchiectasis with infection, otitis media and so on; route of administration was intravenous drip;dose 0. 9-2. 7 g/d, concentration 6-12 mg/ml;AKI occurred at 20 min-7 d after administration. All the patients stopped using clindamycin, after confirmed diagnosis and symptomatic treatment was given. 424 cases were cured. Renal function recovered 7-150 d;1 patient died of acute renal failure. Conclusion Almost all cases of AKI occurred during clindamycin intravenous drip, the onset time is 20 min-7 d after administration. The cause is related to many factors, such as the individual and the dose of drug. Doctors are advised to follow the instructions carefully. In the course of administration, the physicians should observe the changes of urine volume and renal function closely, so as to detect AKI as early as possible.
Keywords：ClindamycinDrug toxicityAcute kidney injuryData collection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 62-65 )