Establishment of GMH-IVH Preterm Rabbit Model and Neurobehavioral Evaluation
BAO Li-sha
LIU Fang
Abstract：Objective To establish the preterm rabbit of germinal matrix hemorrhage-intra-ventricular hemorrhage ( GMH-IVH) . Methods 29 premature rabbits were given birth by cesarean section. Then the premature rabbits were randomly divided into two groups;experimental group (n=18) and control group (n=18). Three hours later, the premature rabbits in experimental group were given intra-peritoneal injection of 50% glycerol (10 ml/kg), the preterm rabbits in control group were given intra-peritoneal injection with the same dose of saline. Both groups received the Cranial ultrasound scan check at 24 h after birth. Premature rabbits in experimental group undergoing GMH-IVH was called GMH-IVH model group, the control group not undergoing GMH-IVH in premature rabbits was called normal control group. Presence of GMH-IVH and neurobehavioral assess-ment were checked. Results In experimental group, the incidence rate of GMH-IVH was 83. 33%(15/18) and the incidence rate of GMH-IVH was 11. 11% (2/18) in control group. The incidence rate of GMH-IVH in experimental group was significant-ly higher than that of control group (P<0. 01). The Premature rabbits accepted neurobehavioral assessment on cranial nerves, consciousness and gait at 24 hours after birth. There was no significant difference in the neurobehavioral testing between the nor-mal control group and the GMH-IVH model group (P>0. 05). Conclusion We have established animal models. The changes in this model are similar with clinical behavior characteristics of GMH-IVH in preterm children.
Keywords：Germinal matrix hemorrhage-intra-ventricular hemorrhageAnimal modelPremature infantNeurobe-havioral ManifestationsUltrasonography
Publication Date：2015-09-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )