Retrospective Analysis of 4 Cases of Fulminant Type 1 Diabetes
GU Yan
LUO Jian-hua
WANG Ya-lin
FAN Yuan-shuo
YU Rui-ping
LIU Bo
HE Xi
LI Yu-ke
Abstract：Objective To investigate the clinical diagnosis, treatment features of fulminant Type 1 diabetes mellitus (FT1DM) and improve the level of diagnosis. Methods Retrospective analysis of clinical data of 4 patients with FT1DM admit-ted to the People's Hospital of Guizhou Province during January 2010 and January 2014 was made. Results Symptoms of the pa-tients suffering from FT1DM were characterized by severe ketoacidosis, diversity of symptoms and a rapid onset. The average du-ration was 4. 5 d. All the patients had symptoms of being thirsty and polyuria. And most of the patients had obvious symptoms of nausea, vomiting and abdominal discomfort. 1 patient was admitted for coma. Except for 1 case with pressing pain under the xiphoid bone,,the signs of acute abdominal pain in the other patients were not obvious. 1 case was misdiagnosed as acute gastro-enteritis, and was given glucose treatment, and then the condition aggravated and the patient was transferred to our hospital. The level of blood glucose at random was 28. 3~46. 5 mmol/L, glycosylated hemoglobin was 6. 0% ~6. 7%. The mean of FCP was 0. 18 ng/ml and 2 hCP was 0. 30 ng/ml. All the four cases were diagnosised as FT1DM. And all the patients received insulin therapy. The function of pancreatic beta cell function followed up from 0. 5 to 2. 5 years showed little sign of improvement. Con-clusion The metabolic disorder of FT1DM is a serious condition. Its insulin beta cell function will irreversibly fail. The mani-festations are diverse and often combined with multiple organ damage. It tends to be misdiagnosed and has a high mortality rate.
Keywords：Diabetes mellitustype 1Diabetic ketoacidosisMisdiagnosisGastroenteritis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )