Analysis on Clinical Characteristics and Prognosis Factors of Patients with Bone Metastasis from Primary Hepatic Carcinoma
LI Jun
SHUAI Cun-yong
CHEN Li-yu
Abstract：Objective To investigate the clinical characteristics and prognosis factors of patients with bone metastasis from primary hepatic carcinoma (PHC). Methods The clinical data of 103 patients with bone metastasis from PHC in de-partment of oncology were retrospectively analyzed. The characteristics and survival quality were summarized and the prognosis factors for bone metastasis from primary hepatic carcinoma were investigated by Cox model. Results There were 73 cases with multiple bone metastases and 67 cases with a mixed type of bone destruction and the mainly metastases place was the spine bone. The survival times of PHC patients were between 0 and 46 months with a median time of 14. 5 months and survival rates since the diagnosis of bone metastases of 1 year, 2 years and 3 years were 55. 3% , 29. 1% and 12. 6% respectively. Multivariate Cox regression showed that with metastasis to other organs (RR = 2. 67, 95% CI: 1. 51 ~ 4. 72), uncontrolled liver lesions (RR = 3. 02, 95% CI: 1. 75 ~ 5. 21), multiple hepatic lesions (RR = 2. 13, 95% CI: 1. 32 ~ 3. 44) and high AFP at the diagnosis of bone metastasis (RR = 1. 89, 95% CI: 1. 08 ~ 3. 29) were prognostic risk factors. Conclusion The long-term prognosis of patients with bone metastases from PHC is poor. The patients with metastasis to other organs, or uncon-trolled liver lesions, or multiple hepatic lesions, or high AFP are more likely to have poor prognosis.
Keywords：Liver neoplasmNeoplasm metastasisClinical characteristicPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 92-95 )