Analysis of Risk Factors of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt
YAN Nan
BAI Yun-fei
SHAN Zhi-gang
SONG Hua-li
SU Hai-long
ZHU Jian-guo
Abstract：Objective To investigate the causes of hepatic encephalopathy (HE) after the transjugular intrahepatic portosystemic shunt (TIPS) and to put forward preventive measures. Methods 50 patients with TIPS admitted to our hospital during June 2006 and August 2012 were divided into HE group (9 cases) and non HE group (41 cases) according to postop-erative HE. 1 d before and 3 d, 7 d after operation and postoperative HE in effect at the time of the blood ammonia, alanine transaminase and total bilirubin levels were compared. The single factor and multiple factor regression analysis, risk factors of postoperative HE TIPS were summarized. Results Compared with that of preoperative 1 d, in HE group 3 d and 7 d after blood ammonia, total bilirubin levels were significantly higher than those in non HE group (P < 0. 05); in HE group, blood ammonia [(91. 2 ± 32. 5) μmol/ L], total bilirubin [(64. 6 ± 45. 7) μmol/ L] levels were significantly higher (P < 0. 05) during HE. Incidence of Child-Pugh C level of patients with HE was higher than B (P < 0. 05), and A level (P < 0. 01), single factor and multiple factors regression analysis showed that preoperative total bilirubin and blood ammonia levels and liver function classification were closely related with HE. Conclusion The increase of preoperative serum total bilirubin and blood ammonia level and high liver function classification may be independent risk factors for the development of HE, therefore the indications of TIPS should be fully understood before TIPS operation in order to reduce incidence rate and prevent HE.
Keywords：Portasystemic shunttransjugular intrahepaticHepatic encephalopathyBlood ammoniaRisk factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 39-43 )