Clinical Value and Expression of Hmlh1, Hmsh2 and Hmsh6 in Colon-rectal Cancer
CHEN Hai-bin
ZHANG Guo-zhi
LI Shu-Guang
CHEN Jun-mao
WANG Chang-you
WANG Xiao-tao
LIU Yang
XU Hong
Abstract：Objective To study the mismatch repair gene family members' hMLH1, hMSH2, hMSH6 expression and the relationship between the three in colon-rectal cancer and its clinical significance. Methods Immunohistochemical SP method was used to detected 72 cases of colon-rectal cancer for tissues hMLH1, hMSH2, hMSH6 protein expression, and a-nalysis of the correlation and pathological features was made. Results For hMLH1, hMSH2, hMSH6 expression in 72 cases of colon-rectal cancer, tissues deletion rate was 73. 6%, 65. 3 and 43. 1%, respectively. In colon-rectal cancer and hMLH1, hMSH2 expression missing rate and protein expression were correlated to tumor size, differentiation, Dukes stage, lymph node metastasis and distant metastasis (P<0. 05), and but not to gender and age (P>0. 05). hMSH6 protein deletion rate was related with degree of tumor differentiation, Dukes stage, lymph node metastasis ( P <0. 05 ) , but not with gender, age, tumor size and distant metastasis (P>0. 05). hMLH1, hMSH2 protein expression was positively correlated with expression missing in colon-rectal cancer in the (r= 0. 295, P<0. 05). hMLH1, hMSH6 and hMSH2, hMSH6 protein expression dele-tion had no significant relationship (P>0. 05). Conclusion hMLH1, hMSH2, hMSH6 may play an important role in the occurrence of colon-rectal cancer, and the combined detection of colon-rectal cancer may have some reference value in diagno-sis and treatment of colon-rectal cancer.
Keywords：Colon-rectal neoplasmhMLH1hMSH2hMSH6Gene expression regulationneoplasticDNA mis-match repair
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 85-88 )