Efficacy of Trimetazidine for Dilated Cardiomyopathy Associated with Chronic Congestive Heart Failure：a System-atic Review
LI Ling
Abstract：Objective To review the efficacy of Trimetazidine for dilated cardiomyopathy associated with chronic con-gestive heart failure. Methods The documents of randomized controlled trials( RCT) related to the efficacy of Trimetazidine for dilated cardiomyopathy associated with chronic congestive heart failure were retrieved from the databases of CNKI, CBM, VIP, PubMed(1990. 10 ~2014. 10), Cochrane, EMbase(1990. 10 ~2014. 10) and the references of these RCT were re-trieved by hand at the same time. The documents were screened,extracted and evaluated according to inclusion and exclusion criteria,and then given a meta-analysis, using Rev Man 5. 1 software. Results There were totally 14 RCTs (1704 patients) included. The results of meta-analysis were as follows: Trimetazidine could improve the clinical effective rates and cardiac function(OR=4. 18, 95%CI 2. 5~6. 36,P<0. 01. MD=8. 05, 95%CI 7. 49~8. 60, P<0. 01. MD= -2. 84, 95%CI-3. 76~ -1. 19, P<0. 01). Conclusion Trimetazidine can improve efficacy of Trimetazidine for dilated cardiomyopathy <br> associated with chronic congestive heart failure.
Keywords：TrimetazidineCardiomyopathydilatedHeart failureTreatment outcomemeta-Analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 69-73 )